What’s Better: Biologics or Oral Immunotherapy?

Julie Sillar • October 30, 2025
What’s Better: Biologics or Oral Immunotherapy?

If you’ve struggled with severe allergies or asthma, you know how frustrating it can be to chase relief without truly solving the problem. From constant sneezing to asthma flare-ups, allergies are awfully disruptive to daily life. Fortunately, modern allergy treatments have evolved, offering solutions that go beyond symptom management.


Today, options like biologics and oral immunotherapy (OIT) provide hope for those seeking long-term control and even desensitization. Biologics target specific immune pathways to reduce reactions, while OIT gradually trains the body to tolerate allergens safely.


At
Premier Allergy of Texas, we help patients navigate these options with confidence. Let’s break down how biologics and OIT work, explore their benefits, and find out which treatment might be right for you. 


Discover the Allergy Solution That Works for You

Explore Your Treatment Options with Our Experts



Understanding Biologics: A New Era in Allergy Care

If you’re looking for treatment that tackles the root of allergic reactions, biologics for allergies could be the answer. Biologics are medications made from living organisms that target specific pathways in the immune system, helping reduce the overreaction that causes symptoms.


Common biologics include:


  • Xolair (omalizumab) – for severe asthma, chronic hives
  • Dupixent (dupilumab) – for asthma, eczema, nasal polyps
  • Fasenra (benralizumab) – for severe asthma


These work by blocking immune signals (like IgE antibodies) that trigger allergic inflammation, helping reduce flare-ups and improve daily life. Biologics are often used for:



Treatment usually involves in-office injections every two to four weeks. While the benefits like fast relief and better symptom control are impressive, it’s also essential to understand the cost of biologics, as expenses and insurance coverage can vary based on your specific treatment plan.



Understanding Oral Immunotherapy Treatment (OIT): Training the Immune System

Unlike biologic therapy for allergies, oral immunotherapy trains your immune system to tolerate allergens over time. Patients are gradually exposed to small amounts of allergens (like peanuts, milk, or eggs) under medical supervision, helping the body respond more calmly and reducing the risk of severe reactions.


Here’s how oral immunotherapy treatment is administered:


  • Dose increases are done in-office with careful monitoring.
  • Maintenance doses continue at home once the target level is reached.
  • Over time, your immune system learns to tolerate allergens, improving safety and confidence.


OIT is usually recommended for:


  • Patients with food allergies
  • Some individuals with allergic rhinitis or environmental allergies


Benefits and considerations:



  • Pros: Potential long-term tolerance, personalized care, and greater control over allergies.
  • Cons: Daily dosing, ongoing commitment, possible oral immunotherapy side effects during dose escalation, such as mild mouth itching or stomach discomfort.


Oral Immunotherapy vs. Biologics: Key Differences

Both biologics and oral immunotherapy are effective allergy treatments, but they work in very different ways. Understanding how each approach addresses allergic reactions can significantly impact your ability to manage symptoms and improve your quality of life.


Here’s a clear allergy treatment comparison to help you see how they differ:



Aspect Biologics Oral Immunotherapy (OIT)
Goal Reduce allergic inflammation Desensitize the immune system to allergens
Conditions Treated Asthma, chronic hives, nasal polyps Food or environmental allergies
Delivery Injections every few weeks (in-office) Daily oral doses at home after supervised escalation
Onset of Results Weeks to months Gradual, from months to years
Maintenance Continuous injections Daily maintenance dose
Cost/Coverage Often covered by insurance, but can be expensive Usually out-of-pocket or limited coverage



In some cases, biologics and OIT can complement each other. For example, biologics may reduce allergic reactions, making OIT safer or more tolerable for certain patients. At Premier Allergy of Texas, our specialists guide you through choosing allergy therapy that fits your unique needs, lifestyle, and long-term health goals.



Expert Insight and Planning: The PATX Approach

We know every allergy treatment journey is unique. That’s why our clinic offers a full range of allergy treatment options, including biologics and oral immunotherapy, guided by board-certified allergists who create personalized treatment plans for each patient.


We focus on:


  • Safety: Treatments are carefully monitored to minimize risks.
  • Patient education: You’ll understand how each therapy works and how to manage your allergies at home.
  • Evidence-based care: Recommendations are based on the latest research and best practices.


Your journey begins with:


  • Allergy testing to identify triggers
  • Personalized treatment planning
  • Ongoing follow-ups to track progress and adjust therapy


With
Premier Allergy of Texas, you’re taking an active step toward long-term control and a better quality of life.



Your Personalized Path to Allergy Freedom

After receiving the best allergy treatment, a woman finds profound relief from her allergies.

Both biologics and oral immunotherapy offer powerful ways to manage allergies and improve your quality of life. When comparing oral immunotherapy vs. biologics effectiveness, the “better” option depends on your specific needs, lifestyle, and allergy type. Understanding the differences and how each treatment works can help you make a choice that fits your life and goals.


With the right guidance from a trusted allergist, you can gain control over your symptoms and feel confident again in your daily life. Schedule a consultation today and take the first step toward long-term allergy relief.


Find the Right Path to an Allergy-Free Life

Book Your Allergy Consultation Today


Frequently Asked Questions

  • Are there lifestyle changes that improve OIT outcomes?

    Consistency is key. Maintaining a regular dosing schedule, monitoring for reactions, and avoiding accidental allergen exposure during dose escalation can help the immune system build tolerance more effectively.

  • How do I know if I’m a candidate for both treatments?

    A detailed allergy evaluation, including testing and review of your history, helps determine eligibility. Factors such as allergy severity, previous reactions, and overall health all play a role in deciding which therapy (or combination) works best.


  • Can lifestyle or stress affect how well these therapies work?

    Yes. Stress, illness, and other environmental factors can influence immune responses. Patients who manage stress well, maintain a healthy routine, and adhere to treatment plans often see better results.


  • Can children and adults benefit differently from biologics or OIT?

    Age can influence which treatment is most suitable. Some biologics have FDA approval for children as young as 6, while OIT protocols often start with younger children for certain food allergies. Your allergist will tailor recommendations based on age and medical history. 

A boy uses an inhaler while playing, an example of asthma management in school-aged children.
By Julie Sillar September 30, 2025
Asthma doesn’t have to limit kids. Find out how Xolair and Tezspire help children stay active, healthy, and confident in school and sports.
Allergies in kids can affect their overall well-being, often starting with red, blotchy skin and end
By Ericka Marie Banting September 3, 2025
Worried your child’s allergies might be affecting more than just their body? Learn to spot the signs and help them feel safer and more confident.
Woman using an inhaler for asthma relief, highlighting the importance of Xolair asthma medication in
By Julie Sillar August 19, 2025
Breathe easier with the right biologic. Learn the key differences between Xolair and Tezspire to find the best treatment for your allergy or asthma.
A boy with a nebulizer on his face. His mother assists him as she administers his asthma treatment.
June 19, 2025
Tezspire is the latest development in asthma treatment. Consult your allergist at Premier Allergy of Texas if this treatment works for you.
A food allergy specialist in San Antonio administers Xolair for food allergies to a female patient.
By Patricia Rosello May 22, 2025
Learn how Xolair for food allergies can reduce severe reactions to common allergens, offering peace of mind to you and your loved ones.
atopic dermatitis
May 13, 2025
Dealing with dry, itchy skin that won’t go away? Learn everything about atopic dermatitis, its causes, symptoms, and treatment options to finally find relief. Discover expert tips and FAQs.
A specialist explains to a patient how allergy test costs can vary depending on the number of allerg
By Patricia Rosello April 30, 2025
Discover how much allergy test cost with and without insurance, what factors affect pricing, and how to avoid unexpected medical bills.
A woman with severe allergy symptoms holds a tissue to her nose.
By Patricia Rosello March 19, 2025
Learn how hormonal changes from puberty to menopause can cause severe allergy symptoms in women and discover expert tips for effective relief.
A patient is getting allergy shots from her doctor to get long-term relief from her allergies.
By Jadys Diez February 26, 2025
Struggling with allergies year-round? Learn how allergy shots can reduce symptoms, minimize medication use, and improve your life!
A healthcare professional presents a biologic treatment to their patient for managing allergies.
By Jadys Diez January 29, 2025
From in-office visits to at-home care, explore how Premier Allergy of Texas offers advanced biologic treatments tailored to you.